Association between proinflammatory cytokines (Interleukin-6 and Interleukin-17) with risk of male idiopathic infertility

Abstract

Background: Infertility defines as the inability to get pregnant after 12 months of unprotected sexual activity. In a healthy testis, the spermatogonia cells, sertoli cells, interstitial cells, and immune cells secrete cytokines that act as intracellular signals to control the differentiation and development of hormones that control reproduction, testicular function, germ cells, and spermatogenesis. Male infertility can result from impaired cytokine production, which can impact how the reproductive system works. Objective: The present study was conducted to estimation of the potential role of proinflammatory cytokines (Interleukin-6 and Interleukin-17) in male idiopathic infertility. Methods: This study was conducted on fifty male infertile patients who were admitted to hospital from the period November /2023 – May/ 2024 and another group consisting of 50 apparently healthy individuals used as controls. Results: The results demonstrated significant elevation of Interleukin-6 and Interleukin-17 levels in the patients group (azoospermia and oligospermia) (14.52±6.27; 12.3±5.76); (15.65±5.32; 13.6±4.42) respectively, when compared with those of control group (7.83±0.61; 6.52±0.75), respectively. Conclusion: Interleukin-6 and Interleukin-17 can be as diagnostic and prognostic biomarker give more accuracy and precise results. Download Full Text