Comparative Study of Some Physiological and Immunological Biomarkers in Women with Polycystic Ovary Syndrome (PCOS) with and without Insulin Resistance (IR)

الملخص

Background: Polycystic ovarian syndrome ( PCOS ) is one of the most prevalent endocrine disorders and metabolic ailments in women of childbearing age. Also, now, closely related to the biology and clinical severity of PCOS is the insulin resistance (IR).Objectives: This study was done to investigate the immunological, hormonal, and metabolic indicators between the healthy controls, patients with PCOS and IR, and patients with PCOS only. Methods: A case-control study involving 50 patients with PCOS having IR ,and 50 patients with PCOS without IR and 50 as a healthy controls. Fasting blood glucose (FBG), HOMA-IR, insulin, LH, FSH, testosterone, IL-18, TGF-β, TLR4 and adiponectin were measured and statistically analyzed. Results: FBG (116.84 ± 14.3 mg/dL), HOMA-IR (5.47 ± 1.05) also insulin (23.87 ± 4.28 mIU/L) were significantly higher with PCOS patients having IR compared to PCOS patients only (FBG 98.88 ± 7.67, HOMO-IR 2.09 ± 0.88 ,insulin 11.83 ± 2.97 ), and control (FBG 88.20 ± 7.61, HOMOIR 1.42 ± 0.45 ,insulin 6.54 ± 2.01) .While the hormonal analysis showed that PCOS – IR exhibited a higher level of LH (16.02 ± 4.6 mIU/mL and testosterone 116.52 ± 15.0 ng/dl) compared to PCOS patients (LH 13.84 ± 3.78, testosterone 84.76 ± 10.7) and controls (LH 4.69 ± 0.61, testosterone 44.72 ± 9.7).While there are no significant found in FSH between all groups .Also, The largest inflammatory load was found in the PCOS -IR group in TLR4, TGF-β and IL-18. While, adiponectin was reduced in PCOS with IR than in PCOS and controls. Conclusion: Such findings illustrate the interactions between metabolic dysfunction, hyperandrogenism and inflammation in the pathophysiology of PCOS, especially in insulinresistant patients. The biomarkers may be convenient therapy indicators and the severity of the disease. Download Full Text